SurModics Pharmaceuticals’ Biodegradable Polyer Products

Prove Experience in Lactide-Glycolide Polymers

SurModics Pharmaceuticals offers both standard grade polymers, maintained in stock, and custom polymers formulated to your specifications.

The Lakeshore Biomaterials^TM product line of standard polymers can be used for feasibility studies or commercial products—and is an effective gauge for evaluating your needs prior to development of your custom polymer.

Once your precise needs are established, we can produce polymers with lactide (L, DL), glycolide or caprolactone monomers and vary the ratios, to design delivery systems and implantable devices with absorption times ranging from weeks to over one year.

Our scientists are the driving force behind our success. They possess expertise in developing polymers that meet precise customer specifications—quickly, efficiently and cost-effectively. And they are always available for consultation. Their goal: to create a product that ensures your success.

Products and Capabilities

 

Our polymers are packaged in flexible, heat-sealed foil pouches, designed to provide a moisture-proof environment for lasting product quality. Foil pouches are shipped in cardboard over-packs for added protection. Other polymers are packaged in Nalgene bottles.

 

Product Naming Conventions

The product names identify polymer mole ratio, polymer identifier, target IV designator, and the end group designation.

 

 

Monomer Ratios :

Monomer ratios can be varied between 0:100 and 100:0 allowing for a broad range of polymer properties.

 

Polymer Identifier :

DLG	poly(DL-lactide-co-glycolide)
DL	poly(DL-lactide)
LG	poly(L-lactide-co-glycolide)
CL	polycaprolactone
DLCL	poly(DL-lactide-co-caprolactone)
LCL	poly(L-lactide-co-caprolactone)
G	polyglycolide
L	polylactide
PEG	poly(ethylene glycol)
C	custom

 

Target Designator :

Target IV Designator	IV Range*	End Group Designators
		Acid	Ester
1	0.05 - 0.15	A	E
1.5	0.10 - 0.20	A	E
2	0.15 - 0.25	A	E
2.5	0.20 - 0.30	A	E
3	0.25 - 0.35	A	E
3.5	0.30 - 0.40	A	E
4	0.35 - 0.45	A	E
4.5	0.40 - 0.50	A	E
5	0.45 - 0.55	A	E
6	0.50 - 0.70	A	E
7	0.60 - 0.80	A	E
8	0.70 - 0.90	A	E
9	0.80 - 1.0	A	E
For custom polymers from 1.0 - 2.0 dL/g call for consultation *(0.5% w/v in CHCL3 at 30 ◦C)

 

End Group :

End group chemistries can be modified to control different polymer properties (degradation and water uptake).

• Ester (E)
• Acid (A)
• PEG

 

Examples:

 

8515 DLG 4E

85 Mole% DL-lactide, 15 Mole% glycolide
IV Spec: 0.35 - 0.45
End Group: Ester

5050 DLG 4A

50 Mole% DL-lactide, 50 Mole% glycolide
IV Spec: 0.35 - 0.45
End Group: Acid

100 DL 1E

100 Mole% DL-lactide
IV Spec: 0.05 - 0.15
End Group: Ester

7525 DLCL 7A

75 Mole% DL-lactide, 25 Mole% caprolactone
IV Spec: 0.60 - 0.80
End Group: Acid

7525 LG 5E

75 Mole% L-lactide, 25 Mole% glycolide
IV Spec: 0.45 - 0.55
End Group: Ester

 

Need more information? Call 205.917.2290